ALBA ON 4000D

Radiative locoregional hyperthermia

Overview

Hyperthermia (HT), heating tumours in the range 41-43°C, is a powerful radio and chemosensitizer. The effectiveness of hyperthermia as well as its safety, in combination with radiotherapy and chemotherapy, has already been proven in phase III clinical trials [1, 2,], particularly in patients with very large or very advanced stages of cancer and recurrent tumours. Hyperthermia enhances the effect of radiotherapy on the tumour, without additional toxicity for healthy tissues, thanks to three synergistic mechanisms:

Inhibition of DNA Repair

Hyperthermia enhances the effectiveness of radiotherapy by inhibiting the repair of DNA damage.

Direct Cell Killing

Hyperthermia selectively kills radioresistant hypoxic tumour cells.

Reoxygenation

Hyperthermia increases tissue perfusion resulting in reoxygenation, thereby reducing hypoxia and increasing radiosensitivity.

With regard to chemotherapy, hyperthermia targets its action within the heated tumour region without affecting system toxicity. It has also been shown that local hyperthermia has the capability of inducing systemic anti-tumour immune responses.

ALBA ON 4000D Platform

The ALBA ON 4000D is a radiative hyperthermia system working at a fixed frequency of 434MHz. The unit is equipped with radiative technology curved high-focused microstrip antennas with an integrated water bolus to safely and effectively heat targets, in the range of 41-43°C for 60 minutes, as required by the ESHO (European Society for Hyperthermic Oncology) guidelines.

High-focused molded beam antenna

ALBA ON 4000D is provided with 4 different sized applicators based on CCMA (Contact Curved Microstrip Antenna) technology designed to properly heat at-depth curved human anatomy with a wide range of target area (up to 609 cm²). The integrated conformal water boluses are specially designed for different patient-specific geometries, adaptive RF matching and surface cooling.

High patient comfort

The curvature of the applicators together with the soft integrated water bolus allows an optimal adaptation to the shape of the anatomical sites to be treated, resulting in high patient comfort.

Find out more on the ALBA website

Download the brochure for the full spec (linked below)