ALBA 4D

Ready for your thermodose escalation

Overview

Hyperthermia (HT), heating tumours in the range 41-43°C, is a powerful radio and chemosensitizer. The effectiveness of hyperthermia as well as its safety, in combination with radiotherapy and chemotherapy, has already been proven in phase III clinical trials [1, 2,], particularly in patients with very large or very advanced stages of cancer and recurrent tumours. Hyperthermia enhances the effect of radiotherapy on the tumour, without additional toxicity for healthy tissues, thanks to three synergistic mechanisms:

Inhibition of DNA Repair

Hyperthermia enhances the effectiveness of radiotherapy by inhibiting the repair of DNA damage.

Direct Cell Killing

Hyperthermia selectively kills radioresistant hypoxic tumour cells.

Find out more on the ALBA website. 

Reoxygenation

Hyperthermia increases tissue perfusion resulting in reoxygenation, thereby reducing hypoxia and increasing radiosensitivity.

With regard to chemotherapy, hyperthermia targets its action within the heated tumour region without affecting system toxicity. It has also been shown that local hyperthermia has the capability of inducing systemic anti-tumour immune responses.

Ultrafast electronic phase target collimator

The ALBA 4D system has a RADAR-based technology unit consisting of a multi-beam phased array of 4 waveguide antennas working at 70 MHz radiating 4 beams independently modulated in phase and amplitude to focus the energy onto the target at any depth and location in the pelvis, abdomen and extremities.

Patient-specific adaptive gantry and advanced positioning solution

The motorized controlled movement of the gantry and the waveguide antennas towards the patient allows ALBA 4D to adapt its mechanical configuration to different patient sizes and anatomies, thus enhancing treatment efficiency and patient comfort.

Embedded laser pointing system for optimal cranio-caudal, dorso-ventral and lateral patient positioning. This allows for both reproducibility of the antennas/patient positioning throughout all the treatments, as well as collimation of the antennas/patient configuration with ALBA easyPLAN and PLAN2heat simulation software.

ALBA software to facilitate Hyperthermia treatment

Dedicated software to ease treatment workflow, assist the user in planning treatment and correct settings and enhance treatment quality.

Download the brochure (linked below) to read the full spec.