INTRABEAM® with other applications

More than 10 years ago INTRABEAM® received both FDA and CE approval for the irradiation of solid tumours in all areas of the body. The INTRABEAM® treatment flexibility results in a wide range of oncological applications in addition to breast cancer therapy. Irradiation during neurosurgical interventions, treatment of colorectal carcinomas, skin cancer or spine metastasisare performed in routine therapy and within the framework of clinical studies in a number of centers around the globe.


Cerebral metastases

Post-operative irradiation of brain tumours and cerebral metastases is often delayed due to wound healing problems and long patient recovery times following the operation. INTRABEAM® offers a cost-efficient and immediate treatment subsequent to a stereotactic biopsy. A substantial number of studies have proven the value of INTRABEAM® in the treatment of brain and cerebral tumours in both children and adults.16, 17, 18, 19, 20, 21

Cerebral metastases

Spinal metastases

For the many cancer patients who develop spinal metastases in the course of their disease, percutaneous kyphoplasty and vertebroplasty are a valuable treatment option. By using intraoperative radiotherapy with INTRABEAM® during kyphoplasty or vertrebroplasty, the metastasis can be sterilised and simultaneously stabilised, a process resulting in reduction of the patient’s pain. It also brings back mobility, significantly enhancing the patient’s quality of life. The first clinical trial experience of this approach has yielded very promising results.15

spinal metastases

Oral cancer

Delivering a boost radiation intraoperatively with INTRABEAM® has potential advantages in the treatment of oral cancers. After resection, the margins of the tumour can be sterilised immediately, which may have a positive impact on local recurrence rate. Additionally, the numerous sensitive structures in this anatomical region can be spared due to the steep fall-off of the low-energy radiation emittedby INTRABEAM®. A geographical miss is unlikely since the applicator can be positioned directly in the tumour bed. First study data have convincingly demonstrated the value of this concept.22

oral cancer

Gastrointestinal cancer

In cancer surgery, the ultimate goal is to remove the tumour completely. However, a complete resection of the tumour is not possible in many patients, meaning that cancer cells remain present in thetumour bed or in neighboring structures. Intraoperative radiotherapy with INTRABEAM® can improve local control of colorectal tumors in cases of local recurrence and local advanced tumours.22 The value of INTRABEAM® has also been demonstrated in the setting of laparoscopic hemicolectomy in patients with colon cancer and gastrectomy in patients with gastric cancer.24, 25

gastrointestinal cancer

Endometrial cancer

In endometrial cancer – the most common malignancy of the female genital tract – the use of INTRABEAM® is also feasible and has some potential advantages compared to most commonly used192Ir high-dose rate (HDR) afterloading, which is highly expensive, given the necessary source changes and the complex radiation protection requirements. By comparison, INTRABEAM® can be used in non-shielded spaces with no radioisotopes involved. First clinical trial evidence has proved that it is possible to create a homogeneous cylindrical dose distribution similar to 192Ir HDR afterloading, suggesting that INTRABEAM® can be used effectively in this common female cancer.26

Endometrial cancer

Skin cancer

The versatility of INTRABEAM® is also displayed in the treatment of skin cancer. Particularly in the treatment of non-melanoma skin cancer, irradiation is an important therapy option, primarily for patients with a high surgical risk. In a prospective study, it was shown that intraoperative radiotherapy with INTRABEAM® was as effective in the management of non-melanoma skin cancer as conventional radiotherapy techniques.27 The well-known advantages of INTRABEAM® – precise radiation delivery, low shielding requirements, and cost effectiveness – also held true for the treatment of skin cancer.

Skin cancer

References


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